Acetaminophen was not identified for being mutagenic inside the bacterial reverse mutation assay (Ames check). In spite of this discovering, acetaminophen analyzed good within the in vitro mouse lymphoma assay in addition to the in vitro chromosomal aberration assay utilizing human lymphocytes. In published experiments, acetaminophen has become reported to get clastogenic (disrupting chromosomes) when given a substantial dose of one,five hundred mg/kg/day for the rat design (three.
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Inntak av Paralgin forte og Paralgin important sammen med mat, drikke og alkohol Unngå samtidig bruk av alkohol med dette legemidlet, da det kan forsterke effekten av alkohol og dermed nedsette reaksjonsevnen din. Graviditet og amming Graviditet: Rådfør deg med lege eller apotek før du tar dette legemidlet dersom du er gravid, tror at du kan være gravid eller planlegger å bli gravid. Hvis legen din mener det er nødvendig kan Paralgin forte eller Paralgin key brukes less than graviditet. Du bør bruke den lavest mulige dosen som reduserer smerten din, og behandlingen bør være så kort som mulig.
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Kolesterol er et fettstoff som er nødvendig for kroppen. Det trengs for at kroppen skal kunne produsere hormoner og vitamin A, samt å bygge opp cellevegger og danne gallesyrer.
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Ved langvarig høy dosering av Paralgin forte eller Paralgin major kan effekten av enkelte blodfortynnende legemidler (midler mot blodpropp som warfarin) øke more info og dermed gi større risiko for blødninger. Snakk med legen din om dosering av Paralgin forte eller Paralgin key hvis du også bruker blodfortynnende legemidler.
90 % ved samtidig bruk av rifampicin, at den reduseres med ca. 70 % ved samtidig bruk av rifapentin (daglig dosering), og at den reduseres med thirty-40 % samtidig bruk av rifabutin. Siden den induserende effekten av rifapentin er doseavhengig, vil dosering for eksempel en gang hver tredje dag eller en gang ukentlig vil gi en lavere påvirkning enn daglig dosering.
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Increased rectal doses or an elevated frequency of administration might be used to attain blood concentrations of acetaminophen just like Those people attained following oral acetaminophen administration. Absorption